[全球衛生] 修課筆記20201020

Mycobacterium tuberculosis complex; M tuberculosis, M bovis, M africanum, M canettii, M microti, M pinnipedii, M caprae

Non-tuberculosis mycobacterium(NTM), also called MOTT

Genus: mycobacteria

Family: Mycobacteriaceae

Ghon complex, Ranke complex

hematogenous spread: simon's foci

isoniazide:activation of bacterial catalyze perozidase

KatG mutation

Rifampicin

interefere with the synthesis of mRNA by binding to the bacterial DNA-dependant RNA polymerase

all bacteria acheie resistance to RMP by mutation in RNA polymerase subunit B

PZA pyrazinamide

coverted to pyrazinoic acid by PZase

Ethambutol EMB

Bedaquiline

diarylquinoline drug

target based resistance

non-target based resistance

Rv0678 mutants: clofazimine, bedaquiline